Sema (Semaglutide) Dosage Guide: Weekly Titration and Units

Dosing Guide — 2026-11-11

Sema (semaglutide) is a GLP-1 receptor agonist studied for metabolic and weight-loss research. It's dosed once weekly on a slow upward titration to manage nausea. This guide covers reconstitution, the full titration schedule in syringe units, and vial longevity. The numbers match our Sema 10mg protocol page.

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Reconstitution math

Standard reconstitution: add exactly 1 mL bacteriostatic water to the 10 mg vial.

Metric	Value
Peptide	10 mg
Bac water	1 mL
Concentration	10 mg/mL
Per 10 units	1 mg

Weekly titration schedule

Sema is titrated upward over months, holding each step ≥4 weeks before increasing. Don't skip steps — nausea spikes if you do.

Step	Dose	Units (U-100)
Conservative start	0.25 mg	~2–3 units
Typical real-world start	0.5 mg	5 units
Step up	1 mg	10 units
Step up	1.7 mg	17 units
Target (if needed)	2–2.4 mg	20–24 units

Administration and cycling

Route: Subcutaneous, once per week, same day each week.
Cycle: 3–12+ months common. Usually tapered rather than stopped abruptly — taper over 4–8 weeks if discontinuing.

Side effects and support

Nausea — especially after each titration step; this is why slow titration matters.
Muscle loss risk — eat adequate protein (≈1 g per lb lean mass) and keep up resistance training.
Constipation — common; a fiber supplement helps.
Fatigue and occasional sulfur burps.

Sema vs other GLP compounds

Sema is the single-agonist GLP-1; Triz adds GIP (dual agonist) and Reta adds glucagon (triple agonist). For comparisons, see Reta vs Sema and the Sema research profile. Refrigerate after reconstitution and use within 4 weeks.

Disclaimer: All information presented in this article is for educational and informational purposes only. Platinum Biolabs does not promote or endorse the use of peptides for human consumption. All products sold by Platinum Biolabs are intended strictly for laboratory and research use only. Consult a qualified healthcare professional before making any health-related decisions.