Cagrilintide Dosage Guide: Weekly Titration and Units

Dosing Guide — 2026-11-11

Cagrilintide is a long-acting amylin analog studied for appetite and weight-loss research — often stacked with a GLP-1 agonist. It's dosed once weekly on a slow monthly titration mirroring the Phase 3 REDEFINE schedule. This guide covers reconstitution, the titration in syringe units, and stacking notes. The numbers match our Cagrilintide 10mg protocol page.

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Reconstitution math

Standard reconstitution: add exactly 2 mL bacteriostatic water to the 10 mg vial.

Metric	Value
Peptide	10 mg
Bac water	2 mL
Concentration	5 mg/mL
Per 10 units	0.5 mg
Per 1 unit	0.05 mg

The 2 mL fill is the practical middle ground — it keeps the very low starting doses measurable without needing sub-unit precision.

Weekly titration schedule (REDEFINE-style)

Weeks	Dose	Units (U-100)
1–4	0.25 mg	5 units
5–8	0.5 mg	10 units
9–12	1 mg	20 units
13–16	1.7 mg	34 units
17+ (maintenance)	2.4 mg	48 units

If GI effects flare at a step, hold an extra 2–4 weeks — or drop back one step — before escalating. There's no rush to reach 2.4 mg. One 10 mg vial yields roughly 4 full maintenance doses at 2.4 mg.

Administration and cycling

Route: Subcutaneous, once per week, same day each week (abdomen, thigh, or upper arm; with or without food). Rotate sites.
Cycle: 3–12+ months common. Not traditionally cycled — run to target, then hold maintenance or taper over 4–8 weeks rather than stopping cold.

Stacking with a GLP

Cagrilintide is frequently studied alongside a GLP-1 agonist (amylin + GLP) — in trials, combination produced more weight loss than monotherapy. If stacking, start both low and titrate one at a time so you can tell which compound drives any side effects. See the Sema dosage guide and Triz dosage guide.

Side effects and support

Nausea/vomiting — dose-dependent, usually worst early and after steps, transient with slow titration.
Constipation — common (fiber supplement helps).
Protein (≈1 g/lb lean mass) + resistance training to preserve muscle.

For the broader weight-loss picture, see best peptides for weight loss research. Refrigerate after reconstitution and use within ~4 weeks.

Disclaimer: All information presented in this article is for educational and informational purposes only. Platinum Biolabs does not promote or endorse the use of peptides for human consumption. All products sold by Platinum Biolabs are intended strictly for laboratory and research use only. Consult a qualified healthcare professional before making any health-related decisions.